DIRECTOR WESAN RAFFAELE-TELETHON INSTITUTE YEGENE THERAPY AKAPIWA NEMUPIRO WAKE WAKAKOSHA KUKUKURUDZISA KWEZVINHU ZVINOSHANDA GENETIC VECTORS.
yevashandi vevanyori
Luigi Naldini, mutungamiriri weSan Raffaele-Telethon Institute yeGene Therapy (SR-Tiget) weMilan uye purofesa akazara weHistology uye Gene uye Cell Therapy pa iyo Vita-Salute San Raffaele University, akagamuchira mubairo weLifetime Achievement Award Phacilitate Lifetime Achievement Award 2024 mukucherechedza basa rake se piyona mumunda wekurapa kwemajini uye kukanganisa kwekutsvakurudza kwake mukurapa zvirwere zvakakomba, genetic asi kwete chete. Kunyanya, Naldini anozivikanwa sa "baba" ve lentiviral vectors, maturusi ekurapa zvino anoshandiswa zvakanyanya mumakiriniki uye anobva kune. humwe hwehutachiona hwevanhu hunotyiwa zvakanyanya, HIV.
Iyo Phacilitate Advanced Therapies Award inocherekedza hunyanzvi mumunda wekurapa kwepamusoro uye zvakapinda zvakatongwa ne jury yenyanzvi dzepasirese inomiririra masangano ekutsvagisa, mayunivhesiti uye indasitiri yebiotechnology mumatanho maviri ekuongorora maitiro. Yakavambwa muna 2023 nemubairo kuna Carl June wekuvandudza kweCAR-T cell therapy. Mhemberero yemubairo we2024 yakaitika Ndira 18 muMiami, Florida, sechikamu cheVhiki yeAdvanced Therapies, nekubatanidzwa kwenharaunda huru yesainzi.
"Muzvinafundo. Naldini inomiririra zvakakwana pfungwa ye 'innovator'. Kuzvipira kwake kusingazununguki pakuvandudza marapirwo anobatsira varwere kwakamuita kuti iye nechikwata chake vasaore mwoyo nekutadza kwekutanga uye kugadzira marapiro ari nani uye anowedzera akachengeteka. Pasina kuzvipira kwake uye kutsungirira kwake, kurapwa kwemajini kwaisazove kwazviri nhasi, kunokwanisa kushandura hupenyu hwevarwere nekuda kwemishonga ikozvino yakatenderwa zvirwere zvemajini zvakaita seADA-SCID uye metachromatic leukodystrophy, tisingarevi mamwe akawanda achiri mukukura kwekiriniki.” anodaro Sven Kili, purezidhendi wedare redzimhosva remubairo wePhacilitate.
Mushure mekupedza kudzidza muMedicine uye Surgery uye doctorate muCytological uye Morphogenetic Sayenzi muTurin, pakati pemakore makumi mapfumbamwe Luigi Naldini akatamira Salk Institute yeLa Jolla (USA), pakushanda naInder Verma naDidier Trono airatidza mukana wekutamisa majini ekurapa nekushandisa hutachiona hwehutachiona hweHIV uye akavaka prototype yemalentiviral vectors ari kushandiswa pasi rese. Mushure mechiitiko chenyika yebiotech yeSan Francisco Bay Area, maakawedzera kukwenenzvera ma lentiviral vectors kuti ashandise zvakachengeteka mukiriniki, akadzokera kuItaly academia, kutanga muTurin uyezve kuMilan. Kubva 2008 zvave mutungamiriri we SR-Tiget uye akaenderera mberi nenzira yekuvandudza tekinoroji yelentiviral, achiiunza pamwe nemupiro weiyo yese Institute kune yayo yekutanga uye inoshanda yekiriniki miedzo. Anga atova mutungamiri weEuropean Society yeGene uye Cell Therapy (ESGCT) uye nhengo yeEMBO, European Molecular Biology Organisation, mumakore apfuura akagamuchira kucherechedzwa kwakakosha, kusanganisira: Mubairo Wakabudirira Wekubudirira kubva kuAmerican Society of Gene uye Cell Therapy mu. 2014 uye neESGCT muna 2015, Mubairo weJiménez Diaz muna 2016, Mubairo weVan Beutler weAmerican Society of Hematology muna 2017 uye, muna 2019, Mubairo weJeantet-Collen weKushandura Mushonga. Akagadzwawo "Grand Officer weOrder of Merit yeItaly Republic" muna Zvita 2019.
"Ndinotenda vadzidzisi vangu uye kune vandinoshanda navo vakanaka uye vadzidzi vakanaka vakandiperekedza murwendo rwakashamisa urwu kubva pakaunda kuenda kumubhedha wevarwere wakatora makore anoda kusvika makumi matatu, vachigovera kurudziro, matambudziko nekuvhiringidzika uye, pakupedzisira, budiriro. Ndinotendawo nhengo dzedare redzimhosva, dzaida kundipa mubairo uyu weupenyu hwese. Ndicharamba ndichishanda nesimba idzva uye nechido mukutsvaga mhinduro dzinobva pajene uye cell therapy kune varwere vazhinji vanoda kurapa kwehunyanzvi kugadzirisa zvirwere kusvika zvino zvave kuuraya" commented Luigi Naldini pachiitiko chekupa mubairo.
Iyo mibairo yakawanda yakawanikwa inotsikirira kuti Naldini aive munhu akakosha sei mukati kuvandudzwa kwegene therapy uye mukushandiswa kwelentiviral vectors yekuchinjisa majini nekuda kwekurapa.. Izvi, pamusoro pekuve pakati pezvishandiso zvakanyanya kushandiswa mumunda we biomedical research, zvakatoshandiswa zvakanyanya mundima yekiriniki. Vakarapwa kuSan Raffaele Hospital chete anenge zana yevarwere vane zvirwere zvakakomba zvemajini zvakadai semetachromatic leukodystrophy, Wiskott-Aldrich syndrome, beta thalassemia uye mucopolysaccharidosis type 1, nekuda kwemasero eropa anogadziriswa achishandisa lentiviral vectors.
Muchidimbu, munyika vanopfuura 400 vanhu akagamuchira kurapwa kwakavakirwa pamasero eropa akagadzirwa nema lentiviral vectors e19 akasiyana pathologies. Vazhinji vevarwere ava - avo vangadai vasina tariro yekupona muzviitiko zvakawanda - vava mumamiriro akanaka uye vanotungamira hupenyu hwakajairwa kana huri nani. Ina yeaya marapirwo akatowana mvumo yekushambadzira: pakati peizvi, gene therapy ye metachromatic leukodystrophy, akaberekerwa mumarabhoritari eSR-TIGET Institute uye kubva muna Zvita 2020 anga ari mushonga wakanyoreswa muEuropean Union uye iyo mvumo inotarisirwa zvakare munguva pfupi iri kutevera muUnited States.
Uyezve, chikamu chikuru chemavector zvakare chakavakirwa pane lentiviral vectors CAR-T varikuedzwa kukiriniki kana kuti vakatobvumidzwa kushandiswa mukutengesa pasirese: iyi mishonga yemagene therapy ine chinangwa chekurwisa marudzi akasiyana eropa kana akasimba mabundu ematishu nekusarudza zvombo zvemurwere anouraya lymphocytes kurwisa tumor cell. Zvinonzi kusvika pari zvino pane vanhu vanodarika mazana matatu nemazana mashanu vakabatsirikana nerudzi urwu rwekurapa.
Tsvagiridzo yekuyedza yaLuigi Naldini inoenderera mberi nekupa mazano ekugadzirisa wedzera zvikumbiro ye gene therapy uye kuwedzera kuivandudza kushanda nesimba uye kuchengeteka. Mumakore achangopfuura, gene therapy zano rine anti-tumor chiito rakagadzirwa zvichibva painjiniya yemasero eropa: masero emwanasikana anogadzirwa ne stem masero - kunyanya monocytes, chena masero eropa - anokwanisa kunangwa uye anoshanda pabundu. nhanho, zviratidzo zvine simba zvinomutsa mhinduro yekudzivirira, kuchengetedza muviri wese kubva pamhedzisiro. Iri zano richiri kuongororwa muchipatara cheSan Raffaele neBesta muMilan kuitira kurapwa glioblastoma, inowanzoitika uye yakakomba bundu muuropi muvakuru. Chidzidzo ichi chinotsigirwa ne Genenta Science, yekutanga-yekutanga yakavambwa naNaldini neSan Raffaele uye nhasi yakanyorwa paNasdaq.
Uyezve, marabhoritari yaNaldini yakabatsira kubva pamatanho ekutanga ekuvandudzayakanangwa gene editing, zvaitwa nhasi ne CRISPR tekinoroji. Zvidzidzo izvi zvinobvumira kutevedzana kwejini kuti inyorwe patsva, kugadzirisa shanduko dzayo pane kutsiva basa rayo neimwe shanduro yakaunzwa nevekita, ichiwedzera iko kurongeka kweiyo genetic manipulation uye kugadzira nzira yezvitsva neshanduko yekushandisa.
Nyorera kune yedu yemashoko!