(by Nicola Simonetti) Some American and Australian research schools have greeted, with scientific interest, the return of the leotard as a daily garment for women and men. Although it is mainly identified as female, models are also on the market for men, who can thus take advantage of its comfort advantages.
The body recognizes a protective and enveloping role, especially of the abdomen and, therefore, preserving the function of internal organs (mainly intestine) avoiding inflammation at risk of induction of neurological damage and, especially, the coupled appendix-Parkinson's disease.
Some research, including a study conducted for 52 consecutive years, out of a million700 thousand Swedish patients, confirmed that Parkinson's originates from the intestine and is associated with changes in the environment linked to pesticide and bacteria interference. Digestive disorders that usually precede (and pre-nunzia) the beginning of parkinsonian symptoms (stiffness, tremors) of several years have ended up on the bench of the accused.
In the appendectomy - this is the initial observation - the risk of getting Parkinson's disease is reduced from 19 to 45 percent.
In the sick appendages, toxic aggregates (alpha-synuclein) have been found identical to those found in Parkinson's neurons, which are found even before the disease breaks out. It is a protein that, in its mutated form, aggregates by killing the neurons of the movement.
The same neuron killer protein has been identified in the context of the vagus nerve, the one that innervates the digestive tract and that - the longest in the human body - connects the intestine (appendix) and brain stations. Therefore, the colon-brain journey of alpha-synuclein at the origin of neurological disease has been intuited and demonstrated.
The appearance of toxic aggregates is more evident and consistent in the diseased appendages in which there are large numbers of cells of the immune system that have the task of controlling the bacteria of the intestinal microbiota (about 1,5 kg of bacteria).
A time bomb ready to explode (probably as a result of an infection or dysfunction due to "environmental sickness") when least expected and to pour its poisons into wagons which, running on the vagus nerve tracks, reach the brain cells and cause Parkinson's
The removal of the appendix (appendectomy) would avoid / reduce this improper traffic by cutting off the bomb-protein traffic.
The counter-proof of this evil journey dates back to 2014 when researchers inoculated these aggregates in the intestinal wall of some mice which, after some time, showed the classic signs of Parkinson's. Another counter-proof derives from the observation of gastric ulcer patients undergoing a section of the vagus nerve (one of the most popular therapies in the past, which aimed to reduce the acidity of gastric juice) in which the risk of Parkinson's disease is reduced by the 20-25 percent.
Why - wondered the researchers coordinated by Bryan Killinger, of Van Andel Research (USA) - do these aggregates generate Parkinson's only in a certain percentage of subjects? The answer seems to have to be found in pro-inflammatory genetic factors as well as in inflammatory bowel diseases (hemorrhagic rectocolitis) which are also less frequent among those operated on for appendicitis.
So, prophylactic removal of the appendix? No need, says Killinger who proposes, in addition to recommending the preservation of their digestive system and preserving it from abnormal food stresses, a possible prevention with anti-alpha-synuclein drugs that would become the first pharmacological prevention of a neurodegenerative disease.
The leotard, with its wrapping role (the elasticized fabric would have a favoring role), of adherence, and with the closure under the crotch would block situations attributable to the vagaries of the temperature and the frequented environments. Skirt and pants could not do the same. The body, defined as a "good brake light" with the only recommendation that the fabric that composes it lets the body breathe.
A curiosity: James Parkinson, the author who first described the disease and took his name from him, was the first English doctor to have documented a case of appendicitis.